Only one out of every two adult patients survive acute myeloid leukaemia.


Thorsten J-rgen Maier from the Institute for Pharmaceutical Chemistry demonstrated that the leukaemic stem cells in a subgroup of AML could possibly be selectively and effectively attacked by 5-LO inhibitors. This was demonstrable in cell culture models and also in leukaemia mouse versions. These results supply the basis for the potential execution of 5-LO-inhibitors as stem cell therapeutic agents for a sustained AML get rid of, although this must be investigated additional in preclinical and medical studies in humans, explains Dr. Ruthardt.In SPCG-4, the decrease in the death rate attributed to radical prostatectomy increased with the real number of years of follow-up, as shown by a member of family reduction at 18 years of 44 percent and a growing difference in rates of loss of life from prostate cancer; this means that that radical prostatectomy prevented deaths from tumors over a wide range of growth prices. Every third man who was assigned to watchful waiting around had passed away from prostate tumor or from other causes, but with metastases present, whereas in the radical-prostatectomy group, every 5th man died.