Hypertensive nephrosclerosis is a common kidney disorder where the smallest arteries in the kidneys.


African Americans at increased threat of kidney failure due to hypertension Of demographics Regardless, African American patients with hypertensive nephrosclerosis have an increased rate of developing end stage renal disease than dying prematurely, according to a report appearing within an upcoming problem of the Journal of the American Society of Nephrology . Previously studies showed patients of all races with Chronic Kidney Disease had been at greater risk of dying prematurely from cardiovascular disease than achieving ESRD.In a proof-of-concept phase 2 trial, we discovered that the administration of cyclosporine immediately before main percutaneous coronary intervention decreased the myocardial infarct size in patients with STEMI.11 In the current phase 3 trial, we investigated whether a single intravenous dosage of cyclosporine, administered immediately before PCI, would improve clinical outcomes and stop adverse left ventricular remodeling at 1 year in sufferers with anterior STEMI. Strategies Study Design The Will Cyclosporine Improve Clinical Final result in ST Elevation Myocardial Infarction Patients trial was an international, investigator-driven, multicenter, randomized, double-blind, placebo-controlled trial, which was coordinated by the Hospices Civils de Lyon.12 This trial was performed in accordance with the principles of the Declaration of Helsinki and the European recommendations once and for all Clinical Practice.