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This kind of damage could be benign, which means it takes place over an interval of years. Although it does not lead to kidney failure often, in some patients this type of kidney disease progresses extremely and the individual develops kidney failure quickly. Hypertensive nephrosclerosis accounts for about 1/3 of new instances of kidney failing in African-Americans. Tahira Palmer Alves MD, MPH , senior author Julia Lewis, MD and colleagues studied individuals from the African American Research of Kidney Disease and Hypertension trial and cohort phase. The AASK trial had 1094 participants enrolled, 764 of whom completed the trial phase lacking any event and 691 of those , subsequently signed up for the cohort phase.